Human Growth Hormone History
Scientists have known the existence of Human Growth Hormone as early as the 1920s. It was not until 1958 before they began to apply HGH on children that suffer from dwarfism to help them grow normally. The effects were very obvious. The theory behind the use of HGH in those days was that the pituitary gland, which secrets HGH, was either defective or not functioning at all in those children with dwarfism. The main source of Human Growth Hormone for treatment at that time was extracted from the pituitary glands of dead people in Africa. It often took thousands of brains of the dead to produce just a few drops of HGH! Scientists were, therefore, forced to research alternatives such as synthetic HGH. In 1985, Genentech succeeded in producing large quantities of HGH through microbiological replication by inserting human DNA into microorganisms. HGH has 191 amino acids. Genentech was able to produce Human Growth Hormone with 191 amino acids by using bio-engineering of the genes.
In 1985, Dr. Daniel Rudman, a Wisconsin internal medicine scholar, first published in the Journal of American Geriatrics Society a brand new theory about aging based on his many years of extensive clinical experiments and research. He indicated clearly in the article that human aging is a result of HGH deficiency, and is not the commonly accepted view of "inevitable natural phenomenon." He further concluded that by stimulating the pituitary gland with HGH, the gland could be made to recover its function to secrete HGH again. This discovery not only stops the aging process but also turns back the biological clock to its adolescent stage.
In July 1990, Dr. Daniel Rudman published another article in the New England Journal of Medicine that shocked the entire medical fields. This article became a milestone in anti-aging treatment with the clinical trials of HGH. He selected 12 males, aged from 61 to 81 for treatment. After 6 months' use of HGH, their fat was reduced by 14.4%; skin thickness increased 7.11%; bone density increased 1.6%; liver improved 19% and spleen improved 17%. Dr. Rudman concluded that these 12 old men had become younger by 20 years both physically and psychologically.
Encouraged by Dr. Rudman's HGH theory, the National Institute on Aging began in 1992 to carry out nine clinical experiments that took 5 years to complete. The results, unprecedented and far-reaching in influence, proved once again that Dr. Rudman's theory was correct.
In 1996 Dr. Rudman had over 800 Human Growth Hormone HGH patients, including movie stars, corporate executives, other renowned doctors, specialists and scholars. In his medical reports, he indicated that among thousands of patients, there was not even one single case of failure.
Within the past ten years, there were more than 30,000 case reports, the results were very encouraging. In 1996, FDA finally approved the usage of HGH in the treatment of both children and adults for suffering from growth hormone deficiency. It is now recognized in the medical fields that HGH is the major hormone among all hormones. It guides and promotes the release and secretion of other hormones.
To make HGH popular and easier to use, an oral delivery system has been developed. It takes advantage of the short distance between the brain and the mouth so that HGH can pass through the mucous membrane under the tongue into the blood vessels within seconds, then it goes directly into the brain. It is quickly absorbed and works to stimulate and reactivate the functions of the pituitary gland to secrete HGH and other rejuvenating hormones. Due to its low but proper dosage, there are no side effects. It is also affordable based on its reasonable price.
What is Human Growth Hormone HGH?
Human Growth Hormone, or HGH, is a hormone that stimulates growth and cell reproduction. Somatotrophin is the name of the HGH hormone that is naturally produced in humans and other animals. Until recently HGH was only used clinically to treat adult growth hormone deficiencies and children's growth disorders. HGH is naturally secreted during sleep, exercise, and stimulated with good nutrition. To now please see our products page.
How Does HGH Work?
To answer the question, "How Does HGH Work ? we first need to define another question: "what is HGH?" This is a question that many people are asking these days. Before you HGH, it's a good idea to understand what it is, so that you can evaluate whether it's worthwhile.
So, just what is HGH? HGH stands for Human Growth Hormone. As the name implies, this hormone is responsible for growth in children and adolescents. HGH levels peak in late puberty and gradually decline thereafter. By age 40 most people are deficient in HGH, and in old age, HGH levels have typically declined by more than 90% from peak production.
In answering the does HGH work question, it's important to realize that this hormone doesn't just affect growth. It's actually considered a "main" hormone that plays an important role in just about every bodily function, and many of the signs of aging are linked to low Human Grwoth Hormone levels. These include reduced muscle mass and added body fat, lower energy levels, decreased sex drive, and a greater risk for chronic illnesses like cardiovascular disease and diabetes. Many people HGH supplements to combat these problems.
Types of HGH
HGH in the injectable form is available with a prescription. Injectable HGH (human growth hormone) is more potent as it is injected directly into the bloodstream. There are however a few drawbacks; injectable HGH carries a hefty price tag, ranging anywhere from $1000-$3500 a month. Injectable HGH may also have some adverse side effects due to its potency. And if it had to be mentioned, there is also the concern of constant needles and injections.
There are many Human Growth Hormone dietary supplements now sold all over the internet and in health stores. Note these forms of HGH, Human Growth Hormone, do not actually contain any true growth hormone. They are just simple another scam, someone trying to make a buck off the popularity and effectiveness of real 191 amino acid Growth Hormone.
An over-the-counter form of HGH called homeopathic HGH is now widely available. They are produced in pill-form, and are as easy to take as vitamins! HGH pills are not as effective as HGH injections, and visible results can take up to 6 months to show. HGH pills however are much gentler on the body versus injections.
HGH is now also available in spray form. According the spray HGH manufactures, homeopathic oral spray HGH is much cheaper than injectable HGH, and one is able to achieve 60%-80% of the results faster but these have never been shown or proven in any medical studies.
Cost of HGH
If you are looking to HGH supplements, compare how different products stack up in terms of price. The injectable form of growth hormone is expensive, ranging from hundreds to thousands of dollars for just a one month supply. This form of HGH is only available by prescription, and carries certain health risks.
In contrast, if you HGH in the form of homeopathic supplements, you can generally HGH at a cost of less than $10 per week. Oral sprays are the quickest acting and most easily absorbed form of HGH. You figure it out for yourself which product is really going to work. Do you really think something costing just a few bucks a week can do much for you?
Where to HGH
The best way to HGH is from a reputable online retailer like us. We offer a very low minimum purchase to help you feel comfortable making your first purchase from us. Many websites require you to make some larger volume purchase to do business with them and/or to get a reasonable price on HGH. We always offer the very lowest price possible to every customer. Always be concerned if a website tells you that you must order a large amount for your first order. This is likely to be someone that is not in business to take care of their customers.
Is HGH Safe?
Like all optional therapies, there will be side effects, and Human Growth Hormone is no exception. Reported side effects of HGH are minor joint pain, excessive body hair growth, water retention, liver and thyroid damage, and even in rare cases abnormal bone and cartilage growth! Most side effects of HGH can be avoided by regulating your intake of HGH. It is recommended that someone starting HGH therapy should start taking HGH at the lowest dose to see how the body will react.
Dr. Richard Hellman, the president of the board of directors of the American Association of Clinical Endocrinologists (AACE), answered our viewers' questions about human growth hormone. Read his answers below and thank you for your questions.
Human growth hormone may not give athletes the edge they're seeking, a new study reports.
Hellman is also a member of the executive committee of the AACE and chairs its patient safety committee. He is a Fellow of the American College of Endocrinology (ACE), and a Fellow of the American College of Physicians. Now!
Question: What are the major side-effects of taking growth hormone? Do you know of any heart or muscle or joint problems? And if so, is there any time frame or dosing issues that affect them?
Gary from San Antonio, Texas
Hellman: When growth hormone is given to replace the growth hormone that is lacking, such as when a child or adult is proven to be without the capability to make their own growth hormone, if the growth hormone replacement is given in the appropriate dosage, the side effects are minimal.
In contrast, when growth hormone is given in excess, to someone who already makes adequate amounts of growth hormone, the excessive and inappropriate growth hormone may have many different and unpleasant side effects, dependent upon the age of the person, their health, and the amount of excess of growth hormone given. In this case, arthritis, due to joint overgrowth, entrapment of nerves, such as carpal tunnel syndrome, excessive sweating, elevated blood sugars or overt diabetes, and edema, may all occur. The longer the exposure to the excess, the greater the problem, and the older the person, the more vulnerable they are to some of the side effects noted above.
Question: Are there any natural proven ways to increase HGH output? Maybe certain exercises or diet? Can your body turn its natural HGH production down or off if it is injected for a period of time (like steroids)? Thanks for your help!
Greg from New York
Hellman: The question is whether there are any natural proven ways to increase HGH output. The counter question is why someone thinks it may be a good idea. Since HGH is essential for normal growth, and without it we remain much shorter than we should be, it is not a surprise that the levels gradually diminish as we get older, after HGH helps us grow in height to our full adult height and helps strengthen our bones to their full density, that we should have less of a need for the hormone. In general, the body does better regarding aging when people are active physically and mentally, and not overweight, and with a lower chronic stress level. Interestingly, when people are physically active and less obese, their HGH levels and responsiveness are better, but this may well be a result, rather than a cause.
Like many baby boomers over 50, Beth was feeling her age.
"I just didn't feel good any more. I wasn't sleeping. I just didn't feel right," she said. She took her concerns to Kansas City, Kansas, endocrinologist, Dr. Jackie Springer, who prescribed replacement hormones, including a daily injection of Human Growth Hormone, or HGH, after two rounds of blood testing.
HGH has been used since the 1950s to help children with growth problems, but it stayed under the radar for other uses until 1990, when Dr. Daniel Rudman reported in the New England Journal of Medicine that men taking a six-month course of HGH reduced their body fat by 14.4 percent while increasing lean muscle mass by 8.8 percent. The study included just a dozen men, but it inspired a flood of anti-aging literature touting the benefits of growth hormone, along with countless Web sites selling HGH creams and sprays. Endocrinologists say those products though, are worthless; the body can use HGH only when it's injected.
But even as the number of prescriptions soars, the legal status of HGH is fuzzy.
Use for anti-aging is prohibited, and adult patients, like Beth, must demonstrate through a blood test that their natural levels are below normal. Selling growth hormone without a prescription can land you in prison for five years and carries a $250,000 fine. The drug has been linked in studies to side effects that include joint pain and swelling. Some say it gets even worse: cancer.
"Growth hormone is secreted in our body to promote cell growth, and cancer is unbridled cell growth," says gerontologist Dr. Thomas Perls, who campaigns vehemently against the use of HGH. "It's basically throwing gasoline on the fire."
A link to cancer, however, has not been proven in humans, only in mice. Research has shown that mice with high levels of growth hormone actually live shorter lives than those with low levels. But the doses in those studies were much higher for body weight than those typically given by anti-aging doctors.
HGH certainly packs a punch when it comes to making headlines. According to the coroner, HGH was found in Anna Nicole Smith's body after she died. Sylvester Stallone was detained by Australian customs agents, who accused him of having 48 vials of HGH stuffed in his luggage. His lawyers are expected to enter a plea to that charge later this month. A federal indictment linked HGH along with anabolic steroids to Barry Bonds' growing neck size and home run totals. Bonds told a grand jury he never knowingly took performance-enhancing drugs.
Rudman didn't support widespread use, but studies by others backed up the findings of muscle gain and fat loss. Side effects are still a concern, but many clinicians say they've seen few problems.
"Growth hormone levels drop with age, and I'm just bringing them up to a normal physiologic level," explains Dr. Mark Gordon, a Los Angeles, California, physician who says he aims to give patients the hormone levels of a young adult. "In the course of that return, we see improvement in a whole array of medical conditions." He says he started practicing what he calls "interventional endocrinology" after seeing HGH injections speed recovery from orthopedic injuries.
Beth believes hormone therapy turned her life around. "I run two miles a day. My cholesterol is perfect. My blood pressure is perfect. I feel really good." She was so enthusiastic; she got her husband to join her.
Ed , 64, spent eight years on the defensive line of the Kansas City Chiefs, playing in two Super Bowls before retiring and building up a successful construction equipment business. "I was getting a little sluggish. I wrote it off as, 'I'm just getting older.' But she said, 'Why don't you at least come and take a shot at this?'" He did, and says he felt the effects within a month. "When I woke up, I wasn't fatigued. I noticed in the gym that I was much stronger. I had more endurance. My memory was sharper."
Despite the dire warnings, only a handful of doctors have gotten into trouble for prescribing growth hormone. One of them, though, was Jackie Springer.
In 2004, the Kansas medical board stripped her of her license, saying she prescribed growth hormone, as well as various diet treatments, without performing diagnostic tests. Springer insists she did perform the tests.
After Springer lost her license, the Lothamers say they found another doctor to continue their treatment. "It's not for everybody, but we think it works, so we do it," says Ed.
Perls isn't convinced. "When [clinicians] indicate they're not seeing any side effects, I simply do not trust them. They're running a business." He sighs deeply. "Everyone should stop, because there really is, I think, significant risk of big problems down the road."
HGH human growth hormone research data
It has been concluded by many researchers that one of the primary causes of aging is the decrease of hgh human growth hormone production. The research says that the normal level of circulating hgh is about 10 milligrams per deciliter of blood at age 21, and it's decreased 80% to only 2 milligrams but at age 61. They say it's growth hormone that grows the cells, bones, muscles, and organs, and it is the level of growth hormone after age 30 that slowly robs us of our youth.
The President of the American Academy of Anti-Aging Medicine says that "Aging appears to be due in large part to the drastic decline of growth hormone in the body after adulthood."
After age 30, the secretion rate of hgh drops14% per decade. By 80, most people barely produce enough hgh to build a fingernail, explaining why injuries experienced by seniors take so long to heal.
More HGH Human Growth Hormone Research
Clinical studies of hgh human growth hormone performed over the past 30 years appear to have demonstrated that through intra-muscular injections, hgh can allow users to increase immune function, improve sexual performance, eliminate cellulite, remove wrinkles, lose fat and build muscle mass. One MD who specializes in life-extension, said he studied 202 patients at his clinic that he treated with small multiple daily hgh injections.
Hgh is the master hormone which is secreted by the pituitary gland and is responsible for directly and indirectly balancing the body's critical hormones. He says, "If I can't get the blood level of your hormones to look like that of a twenty year old, you can get all your money refunded." He also guarantees a gain of 8% to 10% percent in muscle mass and a loss of 10% to 12% of body fat every six months if patients are overweight. This MD does this by treating them with hgh along with other hormones continuing every six months until body composition has reverted to that of a twenty year old.
Growth hormone is produced by the pituitary gland a pea-sized structure at the base of the brain to fuel childhood growth and help maintain tissues and organs throughout life. Beginning in middle age, however, the pituitary gland slowly reduces the amount of growth hormone it produces. This natural slowdown has prompted an interest in the use of synthetic human growth hormone (HGH) to stave off the realities of old age. However, there's little evidence to suggest human growth hormone can help otherwise healthy adults regain youth and vitality.
Who needs to take Human Growth Hormone?
Synthetic human growth hormone, which must be injected, is available only by prescription. It's approved to treat adults who have true growth hormone deficiency not the expected decline in growth hormone due to aging.Studies of adults who have a growth hormone deficiency show that injections of human growth hormone can:
Increase bone density
Increase muscle mass
Decrease body fat
Increase exercise capacity
Human Growth Hormone is also approved to treat AIDS- or HIV-related muscle wasting.
The studies are in; HGH (Human Growth Hormone), otherwise known as the "Master Hormone", can effectively fight the aging process. It controls the release of many other hormones in the body. Hundreds of clinical studies have shown that it can raise energy levels, enhance muscle, decrease fat, strengthen the heart, improve cholesterol, sharpen memory, improve sexual function, boost the immune system, improve sleep, and more.
Why is HGH so powerful? To start, HGH is a naturally occurring hormone created in everyone by the pituitary gland. As you grow beyond your early 20's, your natural HGH levels start to decline. That's when you start to notice signs of aging, such as weight gain and lack of energy. By the time you're 60, your HGH levels have decreased by 80% - which explains why healing takes far longer the older we get.
Clinical studies have shown that a 6-month treatment of HGH can reverse the effects of aging by 10-20 years. However, direct HGH therapy is tightly controlled by the FDA; it requires many injections costing thousands of dollars, and is available only by prescription. Almost always these injections are not covered by insurance. Now!
HGH for AIDS Related Wasting
Wasting occurred more often before successful HAART treatment and was defined essentially as an involuntary 10% or greater weight loss. It was often accompanied by diarrhea & fever. Patients lost lean body mass & fat mass and this could accelerate HIV disease progression. Since the advent of HHART wasting should not & I think does not occur as much. But some patients present themselves to the clinic or for care or HIV testing with advanced HIV.
This is a phase 4 study following the FDA accelerated approval of HGH for wasting, to confirm HGH's benefits. This was a double-blind, placebo controlled, multi-center study. Patients with 10% weight loss, a body mass index <20, or weight <90% of the ideal body weight were randomized to 12 weeks of treatment with HGH, 6 mg daily (DD), 6 mg on alternate days (AD), or placebo.
The primary endpoint of the study was to confirm the clinical efficacy of HGH compared with placebo, based on exercise function change as assessed by cycle ergo meter work output from baseline to week 12. The secondary endpoint was the change in lean body mass (was LBM increased) as measured by bioimpedance spectroscopy (BIS). LBM and total body and trunk fat mass were assessed bt DEXA (dual energy X-ray absorptionetry). Quality of life questionnaires were used to assess patient's response to treatment. Below is a review of the adverse events profile for the patients in the study. Now!
RESULTS of Human Growth Hormone
A total of 757 patients (247 placebos, 253 DD, 257 AD) started the study and 646 completed 12 weeks. In the evaluable population (n=555) patients were mostly white (77%) and male (91%). Average age was 41. All patients were on ART with 88% on HAART. 8% Black. 10% Hispanic.
EXERCISE OUTPUT INCREASED
Over 12 weeks cycle ergometry performance significantly increased by 2.60 kj from baseline in the DD group (9.9%), compared to the placebo group. This compared with a 1% decrease in performance by the placebo group. The AD group had an increase in performance work output of 2.35 kj but this improvement was not statistically significant.
LEAN BODY MASS INCREASED
The secondary study endpoint was lean body mass (LBM) as assessed by BIS. LBM increased by 5.21 kg from baseline in the DD group, and by 3.33 kg in the AD group (both were significant, p<0.001), compared to the placebo group (average gain in LBM of 0.6 kg). The difference in gain in LBM between the DD & AD groups was significant (p=0.017). 1 kg equals 2.2 lbs.
BODY FAT DECREASED
Total body fat mass and trunk fat mass decreased (by DEXA) in both the DD & AD groups. Total body fat mass decreased 1.41 kg in the DD group and 1.04 kg in the AD group. Trunk fat mass decreased by 1.23 kg in the DD group and 0.80 kg in the AD group.
BODY WEIGHT INCREASED
Body weight increased by 2.91 kg from baseline in the DD group and by 2.22 kg in the AD group (both significant p<0.001 vs placebo).
The score for patient satisfaction was 51 in the placebo group, 72 in the DD group, and 65 in the AD group. The differences were all significant.
Viral load did not change over the 12 weeks.
HGH and HIV/AIDs Wasting
In HIV disease, human growth hormone is best known as a treatment for HIV-related wasting, although it is not an approved treatment for this condition in Europe. High doses of human growth hormone have been found to increase weight and lean body mass in people with AIDS wasting (Moyle; Schmitt-Rau; Schambelan; Paton). An increase in lean body mass is thought to be important in HIV disease because the loss of lean body mass is the form of wasting most closely related to an increased risk of death.
In August 1996 human growth hormone was granted accelerated approval in the USA for the treatment of AIDS wasting. Studies of up to 12 weeks in duration have found that the drug may stabilize weight or reverse weight loss in people with HIV, although no improvements in survival were seen. The long-term safety and tolerability of human growth hormone are unknown.
In the European Union human growth hormone has been granted Orphan Drug status for the treatment of AIDS wasting, which means that HyGetropin will have exclusive rights to market the product for this purpose in Europe, even though other companies also have their own versions of human growth hormone. The measure is designed to encourage companies to develop drugs in areas where the number of patients likely to benefit is very low.
Two large, randomized trials presented at the 2002 International AIDS Conference in Barcelona confirmed that human growth hormone can reduce abdominal fat and increase muscle in people taking anti-HIV therapies, confirming previous reports.